What is the Origin of Physiological Timelines?

This conceptual term integrates developmental biology, endocrinology, and gerontology, using the idea of a timeline to map the dynamic progression of human function. It recognizes that the endocrine system drives the major shifts in the timeline, from puberty (gonadal hormone surge) to menopause or andropause (hormone decline). The goal is to compress the period of morbidity and extend the period of high-quality function.

What is the Mechanism of Physiological Timelines?

The progression along these timelines is governed by the gradual changes in the pulsatility and amplitude of key regulatory hormones, such as the age-related decline in growth hormone and DHEA, and the shifting sensitivity of peripheral receptors. These hormonal changes influence epigenetic modifications and telomere shortening, which are cellular markers of aging. By modulating the endocrine environment, it is possible to favorably alter the slope of the physiological timeline, thereby extending the healthspan.

Physiological Timelines ∞ Area

Physiological Timelines

Meaning

Physiological Timelines refer to the genetically and environmentally determined sequence of developmental, maturational, and senescent events that characterize the human lifespan, encompassing the predictable changes in hormonal profiles, metabolic capacity, and tissue structure over time. Clinically, understanding these timelines allows for proactive health interventions tailored to the specific biological stage of an individual, moving beyond chronological age to address biological age. These timelines are profoundly influenced by lifestyle and endocrine factors.