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Physiological Testosterone Concentrations

Meaning

The range of circulating testosterone levels in the blood that are naturally maintained by the hypothalamic-pituitary-gonadal (HPG) axis in a healthy individual, specific to their sex, age, and time of day. These concentrations represent the optimal biological milieu required for maintaining muscle mass, bone density, libido, energy levels, and cognitive function without inducing supraphysiological adverse effects. Clinical goals in testosterone replacement therapy aim to restore levels precisely within this established, healthy reference range.