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Physiological Testosterone

Meaning

Physiological testosterone refers to the concentration and rhythmic secretion pattern of the androgen hormone testosterone that is considered normal, natural, and necessary for maintaining health in a specific individual, typically within the established reference range for their age and sex. This concept is central to hormone replacement therapy, where the clinical goal is to restore circulating levels to this natural, pre-deficiency range. Maintaining physiological levels is critical for supporting secondary sexual characteristics, bone density, muscle mass, and neurocognitive function without inducing supraphysiological effects.