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Physiological System Resilience

Meaning

Physiological System Resilience is the intrinsic capacity of the body’s interconnected organ systems, particularly the neuroendocrine and immune networks, to rapidly recover from and effectively adapt to internal and external stressors, maintaining or quickly returning to a state of dynamic equilibrium. This quality is a critical determinant of healthspan, signifying the robustness of homeostatic mechanisms and the functional reserve against disease and aging. High resilience is clinically characterized by a minimal, rapid, and appropriate physiological response to challenge.