The measure of a biological system’s ability to accurately and reliably execute its intended functions without degradation, error, or deviation from its optimal, youthful performance characteristics. High fidelity indicates robust, resilient function across all major endocrine, metabolic, and neural pathways. Preserving this fidelity is synonymous with maximizing longevity.
Origin
The term is borrowed from electrical engineering and signal processing, where ‘fidelity’ denotes the accuracy of reproduction or transmission. Applied to physiology, it describes the quality and precision of biological signaling and response.
Mechanism
Fidelity is maintained by ensuring the clarity of signaling molecules and the responsiveness of their target receptors. Age-related factors like receptor downregulation, increased inflammatory signaling, and accumulation of cellular damage reduce fidelity. Interventions focus on restoring receptor density, minimizing oxidative stress, and ensuring the endocrine glands produce hormones with the correct molecular structure and pulsatile rhythm.
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