Skip to main content

Physiological Substrate Optimization

Meaning

Physiological substrate optimization is the process of ensuring that the body possesses the necessary foundational molecular and cellular components—the substrates—required for optimal function, repair, and hormonal synthesis. This involves correcting deficiencies in key vitamins, minerals, amino acids, and fatty acids that serve as precursors for hormones, neurotransmitters, and cellular energy production. A lack of these foundational substrates directly compromises endocrine signaling and metabolic efficiency, making their optimization a prerequisite for any advanced hormonal therapy.