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Physiological Set Points

Meaning

Physiological set points represent the optimal, tightly regulated target values for various homeostatic variables in the body, such as core body temperature, fasting blood glucose concentration, and systemic blood pressure. These points are maintained through complex, sensitive feedback loops and represent the body’s preferred operational baseline for maximum efficiency and health. Chronic stress, persistent inflammation, and the aging process can cause a gradual, detrimental shift in these set points, leading to a state of allostasis and eventual pathology.