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Physiological Set Point

Meaning

The Physiological Set Point represents the ideal or optimal level at which a specific biological parameter, such as body temperature, blood glucose concentration, or a particular circulating hormone level, is actively maintained by the body’s homeostatic regulatory systems. This concept defines the desired target value for a given physiological variable, around which the body’s negative feedback loops operate to minimize deviation. In hormonal health, a shift in the set point, such as for thyroid-stimulating hormone (TSH) or body weight, often indicates an adaptive change or underlying endocrine dysfunction.