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Physiological Set-Point Defense

Meaning

Physiological Set-Point Defense describes the robust, highly sensitive homeostatic mechanisms the body employs to vigorously resist deviations from established, tightly regulated internal parameters, such as core body temperature, defended body weight, or circulating hormone concentrations. This powerful defense system, mediated largely by the hypothalamus and endocrine feedback loops, actively works to maintain stability and equilibrium even in the face of significant environmental or therapeutic challenges. Understanding this defense is crucial when attempting to induce a lasting, beneficial change in body composition or hormonal equilibrium.