The deliberate, targeted manipulation of the homeostatic set-points maintained by the body’s regulatory systems, particularly those governed by the neuroendocrine network, to achieve a new, healthier steady state. This adjustment moves parameters like insulin sensitivity or basal cortisol out of a pathological baseline toward an optimal functional range. It is an active recalibration of internal regulation.
Origin
The concept originates from systems control theory applied to biology, where feedback mechanisms strive to maintain a target value, or set-point. Adjustment implies that chronic stressors or aging can shift this target, necessitating intervention to reset it favorably.
Mechanism
Adjustment occurs by modulating the afferent signals or the sensitivity of the central regulatory organs, such as the hypothalamus or pituitary gland. For example, optimizing thyroid hormone action can raise the basal metabolic set-point, thereby influencing overall energy substrate utilization. This process requires sustained, precise inputs to overcome established physiological inertia and lock in the new, desired equilibrium.
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