What is the Origin of Physiological Secretagogues?

The term combines 'physiological' (natural, normal function) with 'secretagogue,' which is derived from the Greek 'sekretos' (separate, secrete) and 'agogos' (leading, inducing). The term is fundamental to endocrinology, describing the natural triggers of hormonal release that maintain pulsatility.

What is the Mechanism of Physiological Secretagogues?

Physiological secretagogues bind to specific G-protein coupled receptors on the target endocrine cells, initiating an intracellular signaling cascade, often involving calcium flux or cAMP pathways, that rapidly triggers the fusion of hormone-containing vesicles with the cell membrane. This action results in a pulsatile release of the target hormone, which is the most effective and least desensitizing way to signal downstream tissues.

Physiological Secretagogues ∞ Area

Physiological Secretagogues

Meaning

Endogenous or naturally occurring substances that stimulate the secretion of another specific hormone or substance from an endocrine gland or secretory cell in a manner that closely mimics the body’s normal, rhythmic physiological release pattern. These agents are distinct from pharmacological agonists as they work within the native regulatory feedback loops to maintain homeostatic control. Ghrelin, for example, is a key physiological secretagogue for Growth Hormone.