What is the Origin of Physiological Resistance?

This concept is a generalization derived from specific, well-characterized clinical examples like insulin resistance and leptin resistance, extending the principle to any critical regulatory pathway. The term highlights that clinical dysfunction is often not due to a lack of the signal itself, but rather the inability of the receiving system to correctly interpret and act upon it. This perspective guides therapeutic focus toward improving receptor function and post-receptor signaling.

What is the Mechanism of Physiological Resistance?

The underlying mechanism for physiological resistance is multi-faceted, often involving chronic inflammation, oxidative stress, or excessive signal exposure leading to receptor downregulation or structural modification. For instance, chronic hypercortisolemia can induce tissue resistance to cortisol's own anti-inflammatory effects. Clinical interventions focus on restoring cellular membrane fluidity, clearing chronic inflammatory mediators, and using intermittent signaling strategies to upregulate receptor expression and enhance cellular sensitivity.

Physiological Resistance ∞ Area

Physiological Resistance

Meaning

A broad term describing the diminished sensitivity or impaired responsiveness of a target tissue, cell, or organ system to a naturally occurring biological signal, whether it be a hormone, neurotransmitter, or nutrient. This resistance disrupts the body’s internal communication and is a fundamental mechanism underlying many chronic diseases and hormonal imbalances. It represents a state where the body’s ‘volume control’ for a specific signal is turned down.