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Physiological Replacement

Meaning

Physiological Replacement is a therapeutic principle in endocrinology involving the administration of an exogenous hormone at a dosage, frequency, and route that closely replicates the body’s natural, endogenous production patterns and circulating concentrations. The clinical objective is to restore hormonal levels to a healthy, youthful range without inducing supraphysiological effects or disrupting the native endocrine feedback loops. This approach is the guiding principle for precision Bioidentical Hormone Replacement Therapy (BHRT).