The deliberate and precise application of exogenous agents, bio-identical hormones, or targeted lifestyle interventions to steer an individual’s biological systems toward a clinically defined, optimized functional state. This practice involves influencing endocrine axes and metabolic pathways beyond simple replacement to achieve enhanced health and performance outcomes. It requires a deep understanding of human systems biology.
Origin
This term is rooted in experimental physiology and clinical pharmacology, where ‘physiological’ refers to the body’s normal functions, and ‘manipulation’ denotes active, intentional control. It is a powerful concept in advanced health optimization.
Mechanism
Manipulation is executed by introducing a signal, such as a peptide or a hormone, that interacts with a specific receptor to initiate a cascade of cellular events. This signaling overrides or augments the body’s current homeostatic settings, driving the system to a new equilibrium. The success of the manipulation is confirmed by measurable changes in downstream biomarkers and clinical outcomes.
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