Skip to main content

Physiological GH Secretion

Meaning

Physiological GH secretion refers to the natural, pulsatile release pattern of Growth Hormone (GH) from the anterior pituitary gland, which is characterized by multiple secretory bursts throughout the day, with the largest and most significant pulse occurring during deep sleep. This pattern is tightly regulated by the hypothalamus and is essential for maintaining normal metabolic function, promoting tissue growth, and regulating body composition across the lifespan. The term emphasizes the importance of the natural rhythm and magnitude of GH release, distinguishing it from non-pulsatile or supraphysiological administration.