What is the Origin of Physiological Feedback Loop Control?

This term is a core principle of cybernetics and physiology, where "feedback loop" describes the self-regulating nature of biological systems. "Control" emphasizes the active, regulatory role of the brain and endocrine glands in maintaining set points against internal and external perturbations. The concept has been fundamental to endocrinology since the discovery of hormonal axes.

What is the Mechanism of Physiological Feedback Loop Control?

In a classic negative feedback loop, a hormone released by a target gland, such as cortisol from the adrenal cortex, travels back to the hypothalamus and pituitary to inhibit the release of its upstream tropic hormones, CRH and ACTH, respectively. This inhibitory signal prevents overproduction and ensures precise titration of hormone levels. Conversely, positive feedback loops amplify a signal, as seen in the LH surge preceding ovulation. The efficiency of this control mechanism dictates the body's ability to maintain homeostasis.

Physiological Feedback Loop Control ∞ Area

Physiological Feedback Loop Control

Meaning

Physiological feedback loop control is the foundational mechanism of the endocrine and nervous systems, describing the precise, dynamic process by which the output of a system is continuously monitored and used to regulate its subsequent input. These loops, such as the hypothalamic-pituitary-adrenal (HPA) axis, ensure that hormone concentrations and physiological parameters remain within narrow, homeostatic ranges. Robust feedback loop control is the essence of a resilient, self-regulating biological system, crucial for adaptation.