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Physiological Euthyroidism

Meaning

Physiological Euthyroidism defines the ideal clinical state where the circulating levels of active thyroid hormones, specifically free triiodothyronine (fT3) and free thyroxine (fT4), are maintained within the optimal, narrow range required for the individual patient’s unique metabolic needs, resulting in complete symptom resolution. This state transcends mere biochemical euthyroidism, which is defined by a population-based reference range for Thyroid-Stimulating Hormone (TSH), by prioritizing the patient’s subjective vitality, metabolic function, and overall sense of well-being. Achieving this personalized balance is the ultimate therapeutic objective of comprehensive thyroid hormone replacement.