Physiological Dosing is a clinical methodology that involves administering therapeutic agents, particularly hormones or peptides, in amounts that closely mimic the body’s natural endogenous production and release patterns. The aim is to restore hormone levels to a youthful, optimal range without inducing supraphysiological concentrations that can lead to negative feedback suppression or adverse side effects. This precise, bio-identical approach is a cornerstone of advanced hormone modulation therapy, prioritizing safety and long-term systemic harmony.
Origin
The term is a refinement of standard pharmacology and endocrinology, emerging from the need to distinguish between high-dose, traditional pharmacological interventions and the subtler, restorative goals of anti-aging and functional medicine. The concept is based on the principle of replacement rather than supraphysiological augmentation, respecting the intricate negative feedback loops of the endocrine system.
Mechanism
The mechanism relies on using advanced diagnostic testing, such as salivary or serum hormone panels, to establish an individual’s unique hormonal deficit or suboptimal range. The therapeutic agent is then dosed and timed to replicate the natural diurnal or pulsatile rhythm of the endogenous hormone, ensuring that receptors are stimulated appropriately. This precision prevents the central regulatory glands, like the pituitary, from shutting down their own production, thereby maintaining the integrity of the entire neuro-endocrine axis.
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