What is the Origin of Physiological Dosing Strategy?

This term is a cornerstone of modern bioidentical hormone replacement therapy (BHRT) and functional endocrinology, distinguishing itself from older, less precise pharmacological dosing models. 'Physiological' refers to the natural, normal function of the body, and 'Dosing Strategy' denotes the deliberate, scientific plan for administration. The concept is rooted in the recognition of the body's exquisite sensitivity to hormone concentration and rhythm.

What is the Mechanism of Physiological Dosing Strategy?

The mechanism centers on avoiding the negative feedback inhibition that occurs when hormone levels are abruptly elevated to non-native, high concentrations. By mimicking the body's natural diurnal or ultradian rhythms, for example, with a specific morning cortisol dose or a cyclical progesterone dose, the HPA and HPG axes are less likely to suppress their own production of upstream regulatory hormones. This careful titration maintains the delicate communication within the neuroendocrine system, supporting the long-term health and function of the entire axis.

Physiological Dosing Strategy

Meaning

A Physiological Dosing Strategy is a clinical approach to hormone replacement or supplementation that aims to replicate the body’s natural, endogenous production levels and rhythmic patterns as closely as possible, rather than administering a standardized, supraphysiological dose. This precise method involves using the smallest effective dose, often delivered in a time-released or pulsatile manner, to restore optimal endocrine signaling clarity without suppressing the body’s own hormone production or inducing negative feedback loops. This strategy is foundational in restorative endocrinology, minimizing side effects and promoting long-term hormonal balance.

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Physiological Dosing Strategy

Meaning

Origin

Mechanism

Can My Employer Penalize Me for Not Participating in a Wellness Program Tied to My Health Insurance?

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