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Physiological Depreciation

Meaning

Physiological depreciation is a conceptual term referring to the gradual, cumulative decline in the functional capacity and structural integrity of an organism’s tissues and organ systems over time. This decline is a consequence of persistent cellular damage, including telomere shortening, mitochondrial dysfunction, and the accumulation of senescent cells, which collectively reduce the body’s homeostatic reserve and adaptive capacity. In the context of hormonal health, depreciation manifests as decreased endocrine gland output, reduced receptor sensitivity, and impaired hormone clearance, leading to the clinical presentation of age-related hormonal decline.