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Physiological Crosstalk

Meaning

Physiological crosstalk is a term used in endocrinology and systems biology to describe the complex, bidirectional communication and regulatory interactions occurring between different organ systems, cell types, or signaling pathways within the body. This intricate network ensures that changes in one physiological domain, such as the endocrine system, are appropriately communicated to and compensated for by others, such as the immune or metabolic systems. It represents a fundamental principle of homeostasis, maintaining systemic balance through integrated signaling. Understanding this crosstalk is essential for comprehending the holistic nature of hormonal health and disease.