What is the Origin of Physiological Concentration?

This term is a cornerstone of pharmacology and endocrinology, combining "physiological," relating to the normal functioning of the body, with "concentration," the amount of a substance in a given volume. It distinguishes the body's natural levels from pharmacological or supra-physiological doses used in therapeutic interventions.

What is the Mechanism of Physiological Concentration?

Hormones operate via a concentration-dependent binding to their receptors; the physiological concentration ensures that only the intended target receptors are saturated, triggering the correct biological response. Deviations can cause unintended cross-reactivity with other receptor types or lead to receptor down-regulation, thereby disrupting the delicate feedback loops of the endocrine system. Maintaining this range is critical for long-term health.

Physiological Concentration ∞ Area

Physiological Concentration

Meaning

Physiological Concentration refers to the range of a specific molecule, such as a hormone, neurotransmitter, or nutrient, that is naturally and normally present in the circulation or target tissue of a healthy individual. This concentration is essential for maintaining homeostatic balance and eliciting the appropriate biological response. Dosing outside this range, either too high or too low, can lead to systemic dysfunction.