What is the Origin of Physiological Aging?

The term is a core concept in gerontology, combining 'physiological,' referring to the normal function of living organisms, with 'aging,' the process of becoming older. Its scientific foundation lies in the "Hallmarks of Aging" framework, which identifies the molecular and cellular drivers of age-related decline. In endocrinology, this concept is directly linked to the progressive reduction in key anabolic hormones, often termed somatopause, andropause, or menopause, which are key markers of systemic functional decline.

What is the Mechanism of Physiological Aging?

The mechanism is complex and multifactorial, involving the accumulation of molecular damage, a breakdown in cellular quality control mechanisms like autophagy, and chronic low-grade systemic inflammation, known as inflamm

Physiological Aging ∞ Area

Physiological Aging

Meaning

Physiological Aging is the cumulative, time-dependent decline in the functional capacity and reserve of the body’s organ systems, driven by underlying cellular processes such as telomere shortening, mitochondrial dysfunction, and increased cellular senescence. This process is distinct from chronological age, as it is a measure of biological function and resilience, directly impacting hormonal health through reduced endocrine gland output and diminished receptor sensitivity. Understanding the rate of an individual’s physiological aging is paramount for implementing targeted longevity and preventative hormonal interventions. It is a metric of the body’s intrinsic wear and tear.