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Physiological Age Decoupling

Meaning

Physiological Age Decoupling is the clinical observation and goal of intentionally widening the gap between an individual’s chronological age and their biological or physiological age, effectively slowing the rate of systemic aging. This concept means that while the number of years lived continues to advance, the measurable biomarkers of aging—such as telomere length, epigenetic markers, and organ functional capacity—remain at a younger state. Achieving this decoupling is a central tenet of longevity medicine, focusing on maintaining youthful function at the cellular and systemic levels. It is the practical application of anti-aging strategies.