Question 1

What is the Meaning of Physiologic Hormone Concentrations?

Accepted Answer

Physiologic Hormone Concentrations define the specific range of circulating hormone levels that closely mimic the natural, healthy concentrations observed in young, asymptomatic individuals, including their appropriate diurnal and pulsatile rhythms. This is the clinical standard for optimal hormone replacement, aiming to restore endocrine signaling to a state that is biologically congruent with robust health and function. Achieving these concentrations is necessary to ensure proper receptor binding and downstream cellular responses without inducing supraphysiologic side effects.

Question 2

What is the Origin of Physiologic Hormone Concentrations?

Accepted Answer

This concept is central to the practice of bioidentical hormone replacement therapy and precision endocrinology, contrasting sharply with the broader, less nuanced reference ranges often used in general medicine. The term emphasizes the importance of restoring the body's natural hormonal environment, acknowledging that optimal health exists within a narrower, more functional range than the typical statistical reference range. It is derived from extensive studies of youthful hormone kinetics.

Question 3

What is the Mechanism of Physiologic Hormone Concentrations?

Accepted Answer

Maintaining physiologic concentrations ensures that hormones interact with their target cell receptors with maximum signal fidelity, promoting the correct expression of genetic material and appropriate metabolic and cellular responses. These concentrations are typically achieved through individualized dosing and delivery methods, such as transdermal or subcutaneous administration, which avoid the non-physiologic peaks and troughs associated with oral administration. The mechanism relies on continuous monitoring to maintain the delicate homeostatic balance.

Physiologic Hormone Concentrations

Meaning

Origin

Mechanism

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