What is the Origin of Physiologic Concentrations?

The term combines physiologic, relating to the normal functioning of the body, with concentrations, referring to the amount of a substance in a given volume. It is a foundational concept in endocrinology, established through extensive reference range studies in healthy populations across different life stages. Accurate determination of these ranges guides diagnostic interpretation and therapeutic dosing decisions.

What is the Mechanism of Physiologic Concentrations?

Hormones exert their optimal effects when present within their narrow physiologic concentration range, ensuring appropriate receptor occupancy and downstream cellular signaling without overwhelming the regulatory feedback loops. Concentrations below this range result in insufficient receptor activation and a deficient biological response, while supraphysiologic levels can lead to receptor down-regulation, cross-reactivity with other receptors, and potentially adverse effects due to overstimulation or aberrant signaling.

Physiologic Concentrations ∞ Area

Physiologic Concentrations

Meaning

Physiologic concentrations refer to the range of a specific substance, such as a hormone or metabolite, that is naturally produced and maintained in the circulation of a healthy human body under normal homeostatic conditions. Clinically, the goal of hormone replacement therapy is often to restore levels to these physiologic concentrations, thereby mimicking the body’s natural endocrine function and minimizing the risk of supraphysiologic side effects. This concept is central to the principle of bioidentical hormone therapy.