The maintenance of optimal biomechanical strength, bone mineral density, connective tissue elasticity, and musculoskeletal architecture throughout the lifespan. This is the tangible foundation supporting mobility, strength capacity, and injury resistance.
Origin
This concept draws from orthopedics and clinical physiology, emphasizing the structural framework that supports endocrine and metabolic function. Hormones are vital regulators of the tissues comprising this structure.
Mechanism
Integrity is heavily dependent on adequate signaling from anabolic hormones, particularly testosterone and growth hormone, which promote protein synthesis in muscle and collagen formation in connective tissue. Furthermore, proper calcium homeostasis, regulated by Vitamin D and parathyroid hormone, ensures skeletal strength. Loss of this integrity compromises physical capacity and increases allostatic load.
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