Physical Dominion Restoration is the clinical objective of regaining comprehensive control over musculoskeletal performance, strength, and functional capacity often diminished by aging or chronic conditions. This involves optimizing the anabolic signaling environment, frequently requiring support for anabolic hormones and muscle protein synthesis pathways. We aim to restore the patient’s ability to exert physical influence over their environment. This concept centers on reversing functional frailty.
Origin
This term synthesizes concepts from exercise physiology, sarcopenia research, and functional medicine, focusing on the subjective experience of capability derived from physiological robustness. Dominion implies mastery or control, which is lost when muscle mass and neuromuscular coordination decline.
Mechanism
Restoration operates through synergistic interventions targeting muscle fiber integrity and neuromuscular junction efficiency. Key mechanisms include providing sufficient anabolic substrate, ensuring adequate levels of growth factors and sex steroids to support hypertrophy, and applying progressive resistance loading to stimulate satellite cell activation. Proper endocrine support is necessary to overcome anabolic resistance often seen in older physiology.
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