What is the Origin of Physical Degradation?

This term is a compound of "physical," derived from the Greek physikos (natural, relating to nature), and "degradation," from the Latin degradare (to reduce in rank or status). In a clinical sense, it describes the measurable loss of optimal bodily form and function.

What is the Mechanism of Physical Degradation?

The mechanism underlying physical degradation is multifactorial, involving a chronic shift in the anabolic-catabolic balance towards catabolism, often exacerbated by persistent low-grade systemic inflammation. Reduced levels of hormones like testosterone, estrogen, and IGF-1 diminish the signaling necessary for protein synthesis and cellular repair, while increased oxidative stress and mitochondrial dysfunction further impair the cell's ability to maintain tissue integrity and regenerate effectively.

Physical Degradation

Meaning

Physical degradation, in the context of human physiology and wellness, refers to the progressive decline in the structural integrity and functional capacity of biological tissues, organs, and systems over time. This encompasses a reduction in muscle mass (sarcopenia), bone density (osteopenia/osteoporosis), and the resilience of connective tissues, leading to diminished strength, mobility, and increased frailty. Hormonal decline, particularly in anabolic steroids and growth factors, is a significant driver and accelerator of this age-related biological deterioration.