What is the Origin of Photobiomodulation Therapy?

The term is derived from the Greek words photos (light), bios (life), and the Latin modulari (to regulate). The clinical application of low-level light therapy began with the discovery of lasers in the mid-20th century, and the term PBM was adopted to precisely describe the non-thermal, biological effect of light. It is a recognized modality in physical medicine and is increasingly studied for its systemic anti-aging and metabolic benefits.

What is the Mechanism of Photobiomodulation Therapy?

The primary cellular mechanism involves the absorption of photons by cytochrome c oxidase, a critical enzyme in the mitochondrial electron transport chain. This absorption leads to a transient increase in ATP synthesis, a reduction in oxidative stress, and the release of nitric oxide from its binding site on the enzyme. The resulting cascade enhances cellular respiration, improves local blood flow, and modulates gene expression related to inflammation and tissue repair, thereby optimizing the function of irradiated tissues, including endocrine organs.

Photobiomodulation Therapy

Meaning

Photobiomodulation Therapy (PBM) is a non-invasive clinical intervention that utilizes specific wavelengths of non-ionizing light, typically in the red and near-infrared spectrum, to elicit a therapeutic effect on cellular function. This therapy is employed to reduce inflammation, accelerate tissue repair, and enhance energy production across various tissues, including muscle, nerve, and endocrine glands. PBM offers a drug-free method for modulating cellular physiology, with applications ranging from pain management to hormonal support.