The study of the chemical structure, synthesis, degradation, and biological function of phospholipids, a class of lipids that are the primary structural components of all cellular membranes, including the plasma membrane and organelle membranes. This biochemistry is crucial for cellular signaling, membrane fluidity, and the proper function of membrane-bound hormone receptors.
Origin
This field is a core discipline within biochemistry and cell biology, recognizing phospholipids’ dual role as structural components and as precursors for important signaling molecules. The term emphasizes the chemical reactions and metabolic pathways governing these essential molecules.
Mechanism
Phospholipids form the foundational lipid bilayer of the cell membrane, creating a semi-permeable barrier that controls cellular entry and exit. The composition of the phospholipid tails, particularly the ratio of saturated to unsaturated fatty acids, dictates membrane fluidity, which directly impacts the conformation and signaling efficiency of embedded hormone receptors, such as those for insulin and thyroid hormones. Furthermore, phospholipids can be cleaved by phospholipases to release bioactive secondary messengers, like arachidonic acid, which initiate inflammatory and regulatory cascades.
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