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Phosphodiesterase Type 5 Inhibitors

Meaning

Phosphodiesterase Type 5 Inhibitors are a class of vasodilating pharmacological agents that selectively block the degradative action of the cGMP-specific phosphodiesterase type 5 enzyme. These drugs are primarily utilized in clinical practice for the management of erectile dysfunction and pulmonary arterial hypertension. By preventing the breakdown of a key intracellular messenger, these inhibitors promote smooth muscle relaxation and increase blood flow in specific vascular beds.