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Phosphodiesterase-5 Inhibitors

Meaning

Phosphodiesterase-5 Inhibitors ($text{PDE}5text{is}$) are a class of pharmaceutical agents that selectively block the activity of the Phosphodiesterase Type 5 enzyme, leading to an increase in the intracellular concentration of cyclic guanosine monophosphate ($text{cGMP}$). These compounds are clinically indicated for the treatment of erectile dysfunction and pulmonary hypertension, leveraging their potent vasodilatory effects on smooth muscle. They represent a cornerstone of treatment for conditions involving impaired nitric oxide signaling.