The cognitive benefit, specifically related to enhanced memory function, derived from the supplementation or presence of the phospholipid compound phosphatidylserine (PS), a vital component of neuronal cell membranes. PS plays a crucial role in cell signaling, neurotransmitter release, and maintaining the structural integrity of brain cells. Clinically, optimizing phosphatidylserine levels is a targeted strategy for supporting recall, learning capacity, and overall cognitive resilience, particularly under conditions of stress.
Origin
Phosphatidylserine is a naturally occurring, essential structural component of all cell membranes, with the highest concentrations found in the brain. The term ‘Phosphatidylserine Memory’ arose from clinical research that identified a direct correlation between PS supplementation and improvements in age-related cognitive decline and memory performance. This finding positioned the compound as a key nutrient for neurocognitive health.
Mechanism
Phosphatidylserine is integral to maintaining the fluidity and permeability of neuronal membranes, which is essential for efficient synaptic transmission and receptor function. It helps to modulate the release of key neurotransmitters, including acetylcholine, which is critical for memory and learning. Furthermore, PS has a role in managing the stress response by blunting the excessive secretion of cortisol, thereby protecting hippocampal neurons from glucocorticoid-induced damage and supporting long-term memory formation.
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