Phosphatidylserine Brain Support is the targeted clinical application of the phospholipid phosphatidylserine (PS) to enhance and maintain the structural and functional health of neuronal cell membranes. PS is a vital component of the inner leaflet of the plasma membrane, particularly concentrated in brain tissue, where it plays a critical role in cellular signaling, neurotransmitter release, and synaptic communication. Clinically, this support is utilized to improve memory function, reduce cortisol-induced stress responses, and mitigate age-related cognitive decline. It provides the essential building blocks for optimal neuronal architecture.
Origin
The term is derived from the biochemical name of the compound, ‘Phosphatidylserine,’ and the functional description of its role in ‘Brain Support.’ PS was first identified in the 1940s, and its role in membrane structure has been long understood, but its clinical application for cognitive enhancement gained prominence in the late 20th century. Its use in the hormonal health space is often linked to its documented ability to modulate the HPA axis.
Mechanism
Phosphatidylserine enhances neuronal signaling integrity by maintaining the optimal fluidity and asymmetry of the cell membrane, which is essential for the function of membrane-bound enzymes and receptors. It also plays a direct role in the release of neurotransmitters, such as acetylcholine and dopamine, by modulating the fusion of synaptic vesicles with the presynaptic membrane. Furthermore, PS helps dampen the hyper-responsiveness of the adrenal axis to stress, contributing to a more balanced cortisol profile.
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