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Phenoconversion

Meaning

Phenoconversion, in a clinical and metabolic context, refers to the process where an individual with a favorable, typically genetically-determined metabolic phenotype transitions to an unfavorable, disease-associated phenotype due to the cumulative influence of environmental and lifestyle factors. This concept highlights that genetic predisposition is not destiny, emphasizing the profound impact of epigenetics and modifiable factors like diet, stress, and physical activity on the expression of metabolic health. It is a critical consideration in longevity and wellness, as it marks the point where a person shifts from being metabolically healthy to metabolically dysfunctional.