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PhenoAge Calculation

Meaning

PhenoAge Calculation is a sophisticated method of determining an individual’s biological age based on a composite score derived from nine standard clinical biomarkers and chronological age. Developed by Dr. Morgan Levine and colleagues, this calculation utilizes an algorithm trained on DNA methylation data to reflect an individual’s mortality risk more accurately than chronological age alone. The resulting PhenoAge value represents a person’s expected age based on their physiological profile, providing a powerful, actionable metric for assessing healthspan and the efficacy of longevity interventions. A lower PhenoAge relative to chronological age suggests a slower rate of biological aging.