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Phase Relationship Adjustment

Meaning

Phase Relationship Adjustment is a chronobiological intervention aimed at intentionally shifting the timing of an individual’s endogenous circadian rhythm relative to the external environment or a desired behavioral schedule. This clinical strategy is used to treat circadian rhythm sleep-wake disorders and to optimize systemic function by aligning the biological clock with social and environmental demands. The adjustment is achieved through the precise timing of external cues, or zeitgebers, primarily timed light exposure and/or exogenous melatonin administration. Establishing the correct phase relationship is vital for the harmonious synchronization of all hormonal and physiological rhythms.