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Pharmacological Signaling Noise

Meaning

Pharmacological Signaling Noise is the unwanted or non-specific cellular signaling events generated by a therapeutic agent that interfere with the intended, high-fidelity hormonal message. This noise can result from a drug’s non-selective binding to multiple receptor types, the production of unintended, active metabolites, or the induction of secondary, off-target effects. Minimizing pharmacological signaling noise is a central challenge in drug design and personalized endocrinology, as it contributes significantly to adverse side effects and metabolic signaling dissonance.