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Pharmacokinetics of Progesterone

Meaning

Pharmacokinetics of Progesterone is the quantitative study of how the body processes progesterone, whether endogenous or administered as a therapeutic agent, focusing on the dynamic processes of absorption, distribution, metabolism, and excretion (ADME). Understanding these kinetic parameters is clinically vital for determining the appropriate route of administration, dosage, and frequency required to achieve and maintain therapeutic concentrations of the hormone in the target tissues. Significant variations in pharmacokinetics exist based on the formulation—such as oral, transdermal, or vaginal—directly impacting its clinical efficacy and side-effect profile. This detailed understanding allows for the precise personalization of hormone replacement therapy.