The quantitative study of how a therapeutic agent, whether a pharmaceutical, hormone, or targeted supplement, is absorbed, distributed, metabolized, and excreted (ADME) by the body over time. Understanding the pharmacokinetics of an intervention is essential for establishing the optimal dosage, frequency, and route of administration to maintain therapeutic concentrations and maximize efficacy while minimizing potential side effects. This data-driven approach ensures precision in clinical dosing.
Origin
This is a core discipline within pharmacology, where the term originates from the Greek words pharmakon (drug/medicine) and kinetikos (putting in motion). In the wellness space, it is applied to all bioactive compounds, underscoring the necessity of treating nutraceuticals and hormones with the same scientific rigor as prescription drugs. It provides the mathematical framework for precision dosing.
Mechanism
Absorption dictates how much of the substance enters the systemic circulation; distribution describes its movement to various tissues and target receptors; metabolism, primarily in the liver, transforms the substance into active or inactive metabolites; and excretion determines its final clearance from the body. These four processes collectively define the concentration-time curve of the intervention, which must be carefully managed to achieve sustained biological effect.
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