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Pharmacokinetics of Estrogens

Meaning

The Pharmacokinetics of Estrogens is the clinical study of how the female sex hormones, specifically estrogens (estrone, estradiol, estriol), are absorbed, distributed, metabolized, and ultimately excreted from the human body. Understanding these processes is paramount for designing safe and effective hormone replacement therapy regimens. Key variables include the route of administration, which significantly impacts absorption and first-pass hepatic metabolism, and the resulting half-life and steady-state concentration in the circulation. This knowledge guides the selection of the most physiological delivery method.