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Pharmacokinetics of Aging

Meaning

The study of how the body handles therapeutic agents—specifically, the processes of absorption, distribution, metabolism, and excretion (ADME)—as these processes are progressively altered by the physiological changes associated with human aging. This discipline is essential for clinicians to accurately dose and prescribe hormonal and metabolic therapies for older adults. Age-related changes in body composition, liver function, and renal clearance necessitate a modified pharmacological approach to ensure both efficacy and patient safety. Understanding these dynamics prevents toxicity and maximizes therapeutic benefit.