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Pharmacokinetic Variations

Meaning

Pharmacokinetic Variations refer to the measurable differences among individuals in the absorption, distribution, metabolism, and excretion (ADME) of therapeutic agents, including hormones and medications. These variations directly influence the concentration of the compound that ultimately reaches the target tissue receptors and, consequently, determine the magnitude of the clinical effect. Recognizing and accounting for these individual differences is paramount for achieving precise, personalized dosing and ensuring therapeutic safety. They represent the biological uniqueness of drug processing.