What is the Origin of Pharmacokinetic Titration?

The term is derived from pharmacology, combining 'pharmacokinetics,' the study of drug movement within the body, and 'titration,' the process of adjusting concentration to a desired endpoint. It represents a clinical methodology for individualized dosing.

What is the Mechanism of Pharmacokinetic Titration?

Titration involves serial blood or saliva testing to measure the compound's concentration and its active metabolites over time, providing data on the patient's unique rate of absorption and clearance. This data is used to calculate the necessary dose adjustments to counteract individual variability in liver metabolism or renal excretion, ensuring the concentration remains within the narrow therapeutic window required for effective and safe receptor engagement without undue systemic burden.

Pharmacokinetic Titration

Meaning

The clinical process of systematically adjusting the dosage and frequency of a therapeutic agent, such as a hormone or peptide, based on an individual’s measured plasma concentrations and metabolic clearance rates, aiming to achieve and maintain a stable, optimal concentration at the target site. This meticulous process is guided by pharmacokinetic principles—absorption, distribution, metabolism, and excretion—to ensure predictable and safe drug exposure. Titration is essential for personalized medicine, especially in hormonal therapies.