What is the Origin of Pharmacokinetic Precision Dosing?

This term combines 'pharmacokinetics,' the study of drug movement through the body, with 'precision dosing,' emphasizing exactitude in administration quantity and timing. Its rise is fueled by advances in therapeutic drug monitoring and understanding of individual metabolic variance.

What is the Mechanism of Pharmacokinetic Precision Dosing?

The mechanism involves using patient-specific data, such as body composition, liver enzyme activity, or co-administered substances, to model the required dose to achieve a target Area Under the Curve (AUC) or Cmax. For example, adjusting exogenous testosterone dosing based on the patient's calculated clearance rate ensures steady physiological levels rather than supraphysiological spikes. This systematic modeling drives individualized therapeutic efficacy.

Pharmacokinetic Precision Dosing

Meaning

Pharmacokinetic Precision Dosing is the clinical strategy of calculating drug or hormone administration schedules to maintain systemic concentrations within a narrow therapeutic window, accounting for individual absorption, distribution, metabolism, and excretion (ADME) parameters. This approach minimizes peak-trough fluctuations that can cause side effects or therapeutic failure. It is the application of individualized pharmacology.