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Pharmacokinetic Plateau Achievement

Meaning

The successful establishment and maintenance of a steady-state concentration of a therapeutic agent in the systemic plasma, achieved when the rate of drug absorption into the circulation is precisely equal to the rate of its elimination from the body. Clinically, achieving this pharmacokinetic plateau is the goal of all chronic dosing regimens, as it ensures consistent receptor saturation and stable, uninterrupted hormonal effects. This stable concentration minimizes the risk of sub-therapeutic troughs or potentially toxic peaks.