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Pharmacokinetic Performance Tuning

Meaning

Pharmacokinetic Performance Tuning is the deliberate clinical and formulation process of adjusting a drug or hormone’s pharmacokinetic profile—its absorption, distribution, metabolism, and excretion (ADME)—to achieve an ideal therapeutic concentration curve over time. This high-precision tuning is employed to minimize peak-and-trough fluctuations, prolong the therapeutic window, and closely mimic endogenous physiological release patterns. It represents the optimization of a compound’s behavior within the body for maximum clinical effect and safety.