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Pharmacokinetic Alterations

Meaning

Pharmacokinetic alterations describe changes in the way the body processes a therapeutic agent, specifically encompassing modifications to its absorption, distribution, metabolism, and excretion (ADME). These alterations can be induced by factors such as genetic polymorphisms, concurrent drug use, age-related decline in organ function, or changes in hormonal status. Understanding these shifts is paramount in personalized medicine, as an alteration can significantly impact the effective concentration of a drug or hormone at its target receptor, leading to unpredictable efficacy or increased risk of side effects. This knowledge is essential for precise dosing and regimen adjustments in clinical practice.