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Pharmacogenomics of HRT

Meaning

Pharmacogenomics of HRT is the application of an individual’s genetic profile to predict their metabolism, efficacy, and potential for adverse reactions when undergoing Hormone Replacement Therapy (HRT). This precision approach analyzes genes encoding drug-metabolizing enzymes, such as the cytochrome P450 family, and hormone receptors to customize the type, dose, and route of administration for hormones like estrogen, progesterone, and testosterone. Utilizing this genomic information allows clinicians to optimize therapeutic outcomes while significantly minimizing risks such as thrombosis or undesirable metabolic side effects. This practice is essential for safe and effective hormonal optimization.